| # | Eastern Conference | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Tampa Bay | 18 | 11 | 5 | 2 | 33:19 | 14 | 38 | |
| 2. | Charleston | 18 | 9 | 3 | 6 | 37:24 | 13 | 30 | |
| 3. | Detroit | 17 | 8 | 4 | 5 | 25:17 | 8 | 28 | |
| 4. | Louisville City | 18 | 8 | 3 | 7 | 32:31 | 1 | 27 | |
| 5. | Pittsburgh | 18 | 8 | 2 | 8 | 20:20 | 0 | 26 | |
| 6. | Rhode Island | 16 | 6 | 4 | 6 | 25:19 | 6 | 22 | |
| 7. | Miami FC | 19 | 5 | 7 | 7 | 24:31 | -7 | 22 | |
| 8. | Indy Eleven | 16 | 6 | 3 | 7 | 19:20 | -1 | 21 | |
| 9. | Hartford Athletic | 17 | 4 | 8 | 5 | 12:16 | -4 | 20 | |
| 10. | Loudoun | 17 | 3 | 9 | 5 | 21:29 | -8 | 18 | |
| 11. | Birmingham | 17 | 3 | 8 | 6 | 18:21 | -3 | 17 | |
| 12. | Brooklyn | 17 | 3 | 4 | 10 | 17:32 | -15 | 13 | |
| 13. | Sporting Jax | 19 | 1 | 5 | 13 | 23:51 | -28 | 8 | |
| # | Western Conference | MP | W | D | L | G | GD | Pts | Form |
| 1. | Orange County SC | 18 | 9 | 7 | 2 | 29:19 | 10 | 34 | |
| 2. | San Antonio | 18 | 8 | 7 | 3 | 25:20 | 5 | 31 | |
| 3. | FC Tulsa | 17 | 8 | 5 | 4 | 20:16 | 4 | 29 | |
| 4. | New Mexico | 15 | 8 | 3 | 4 | 20:15 | 5 | 27 | |
| 5. | Sacramento Republic | 17 | 7 | 5 | 5 | 24:16 | 8 | 26 | |
| 6. | Lexington | 17 | 7 | 4 | 6 | 27:22 | 5 | 25 | |
| 7. | Colorado Springs | 17 | 7 | 4 | 6 | 28:24 | 4 | 25 | |
| 8. | El Paso | 18 | 7 | 4 | 7 | 28:27 | 1 | 25 | |
| 9. | Las Vegas Lights | 18 | 6 | 5 | 7 | 25:27 | -2 | 23 | |
| 10. | Phoenix Rising | 18 | 5 | 7 | 6 | 24:25 | -1 | 22 | |
| 11. | Oakland Roots | 19 | 5 | 7 | 7 | 25:28 | -3 | 22 | |
| 12. | Monterey Bay | 19 | 4 | 3 | 12 | 19:31 | -12 | 15 |